Have a combination of experience and education that includes courses comparable to a major in a biological science, agriculture, natural resource management, chemistry or related disciplines appropriate to this position, AND have appropriate experience or additional education that demonstrates similarlyĪppropriate skills or abilities needed to perform the duties of this position. Have completed the requirements for a bachelor’s (or graduate) degree in a biological science, agriculture, natural resource management, chemistry, or related disciplines appropriate to this position, from an accredited college or university To qualify for a Supervisory Biochemist, GS-401-15 position you must meet the following Education Requirements: Using system-level approaches the Senior Scientist would lead the team in creating platforms capable using existing chemogenomics screening capabilities to test pre-defined therapy options for precision treatments.

They will lead the development of disease models that more faithfully replicate diseased cells and tissues using high-throughput capable 3D-cell cultures and organoid-based screening methodologies, with the application of spatially resolved single-cell transcriptomics. Using publicly available datasets, the individual would enable the discovery of multi-component gene modules (pathways) to shift the focus of the genetic-dependency paradigm from individual genes to multi-component pathways to develop novel drug-regimens for specific cancer subtypes. The Director of the P3T Program would lead a team in utilizing multiple paradigms in lead discovery ranging from high throughput screening to fragment based methods to scaffold hopping and will direct staff in developing innovative strategies to pharmacologically modulate currently ‘undruggable’ cellular targets and pathways.

This position serves as a Senior Scientist directing the Precision Therapeutics and Translational Technologies (P3T) Program located within the Chemical Genomics Branch ( CGB), Division of Pre-Clinical Innovation. The program will advance platform technologies that include material and device design along with technologies to detect the biological events being studied. The National Center for Advancing Translational Sciences ( NCATS) is seeking a Senior Scientist with scientific, administrative, and leadership credentials who can lead a program to operationalize the use of biologically inspired, engineered assay platforms for therapeutics discovery and development.

Scaffold resource